Antigen-Specific T Cells for Melanoma Research: Tyrosinase Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Antigen-Specific T Cells for Melanoma Research: MART-1 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Irradiated PBMC as Research Tools Irradiated PBMC are PBMC from normal donors that have been subjected to high frequency ionizing X-Ray or gamma radiation. This exposure creates DNA damage that prevents certain cells (e.g., T cells, NK cells, B cells) from undergoing cell division. Irradiated PBMC components retain cellular functions, such as cytokine secretion, cytotoxicity,…
Neutrophils for Allergies and Inflammation Research Neutrophils are the most abundant leukocyte of peripheral blood and are known as the immune system’s first response to infection and injury. Recent studies have shown neutrophils’ effect in the regulation of both innate and adaptive immune response (A. Mocsai, 2013). Exposure to allergen leads to recruitment of…
FAQs on Using Dendritic Cells for Immuno-oncology and Autoimmunity Research and Development Dendritic cells are a family of immune cells that help to maintain balance in the immune system. The dendritic cell family is typically divided into four subgroups: Conventional dendritic cells (DC1 and DC2) Plasmacytoid dendritic cells Inflammatory dendritic cells Langerhans cells Dendritic cells…
Anti-HPV E7 T Cells and the Fight Against Cervical Cancer Cervical cancer induced by human papillomavirus (HPV) remains a global concern with high mortality rates, especially for women in under-developed and under-served portions of the world. According to the CDC, over 47,000 HPV-associated cancers occur in the United States each year, with women representing about…
Antigen-Specific T Cells for Melanoma Researchers: gp100 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
The Increasing Relevance of Tregs in Immunology and Oncology The study of regulatory T cells in autoimmunity, oncology, and infectious disease is still very much in its early days, though the applicable research findings are piling up. Recent studies have linked the importance of Tregs to key areas of immunology:1 Autoimmune Disease: Tregs have been…
Donor-to-Donor Variation in Response to 3 Critical Recall Antigens Peripheral blood mononuclear cells (PBMC) are useful tools for evaluating immune response because they represent most of the resident immune cells in a donor’s sample, including T cells, B cells, natural killer (NK) cells, and monocytes. Varying Responses to Today’s Most Relevant Antigens In addition…
The Value of Donor Data Transparency in Biomaterial Sourcing In the spirit of open sharing and collaboration between scientists, we make all our donor data available to you as you’re selecting the best human immune cell products for your research. After all, we’re scientists, not salespeople. That means you don’t have to fill out a…
